Minnesota is another team without its starting QB — Teddy Bridgewater wrecked his left knee in practice and is gone for the season. The Vikings dealt for Sam Bradford this week, but how soon he will be ready is a huge unknown.
Some have pegged the Bucs as a rising team, and they have the offense to be dangerous behind Jameis Winston, Doug Martin and Mike Evans. Is their pass rush upgraded enough.
"We don't want to major in putting hurdles out there," coach Rex Ryan said during training camp. "But we seem to be doing a pretty good job of it right now."
Cincinnati at the New York Jets
With Matt Forte gone, it will be intriguing to see what the Bears' running game looks like.
On Monday night, the doubleheader has Pittsburgh at Washington and the Rams — yes, representing Los Angeles — at San Francisco.
"There's so much going on right now," Garoppolo said. "Mentally, I'm straight Arizona, but it is a phenomenal opportunity. This is why you play the game. You play to be in the game and play; you don't want to be the backup. The opportunity is here. I've just got to go take advantage of it."
Detroit at Indianapolis
"It's about two interceptions every day," Arians said. "He flies around and makes every check and has the energy and passion that he always has."
Pittsburgh at Washington, Monday night
The season kicked off Thursday night with Denver's 21-20 victory over Carolina in a rematch of the Broncos' Super Bowl victory. Carolina's Graham Gano missed a 50-yard field goal with four seconds remaining.
Seemingly the focal point for most people watching the 49ers is Colin Kaepernick not standing for the national anthem. Whether he does or not, Chip Kelly debuts as San Francisco's coach.
Even worse, the Seahawks seem to be on a mission, with a nasty defense, productive offense and everything in place for another Super Bowl run — if their offensive line coalesces.
Kansas City also will be minus some key players, including star linebacker Justin Houston and running back Jamaal Charles. Coach Andy Reid said it's "a stretch" to expect Charles to suit up.
If the Jaguars' rebuild is nearing completion, these are the kind of games they need to win. Or at the very least, be competitive.
Chicago at Houston
Minnesota at Tennessee
The Lions have one victory in Indianapolis. In 1991. But their coach, Jim Caldwell, led the Colts to the Super Bowl in 2009. Longtime standout WR Calvin Johnson has retired, a Megatron-size hole Detroit must fill.
Los Angeles at San Francisco, Monday night
That opportunity is thanks to the "Deflategate" saga that finally has played out. Brady is gone for four weeks, and Jimmy G is the guy.
Without Le'Veon Bell in the backfield and Martavis Bryant at receiver (both suspended), the Steelers would appear undermanned. They still have Ben Roethlisberger throwing to Antonio Brown, though, and veteran DeAngelo Williams was a terrific stand-in last year for Bell.
Cleveland at Philadelphia
Oakland at New Orleans
Drew Brees reworked his contract. Now if only the Saints can rework a defense that ranked 31st across the board on the yardage charts in 2015. The hope in the Big Easy is that linebacker James Laurinaitis can spark an already banged-up unit,
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How did coach Bruce Arians know the Honey Badger was ready after the safety missed the preseason?
"I'm playing football," Packers receiver Jordy Nelson said when asked if his knees were an issue as he comes off a torn right ACL in a preseason game last summer at Pittsburgh.
"Wouldn't have expected for it to happen this early, but it did unfortunately," Prescott said. "For it to be a reality now, to be a starting quarterback, it's fun just to get in the huddle and be around a bunch of great guys and get to play in this division."
Atlanta looked dynamic in going 5-0 and 6-2 before fading to 8-8. Although coach Dan Quinn has a solid defensive background, the Falcons were last with 19 sacks in 2015 and must improve that — immediately.
The Browns brought in Robert Griffin III, hoping he can resurrect his QB career after it fell apart in Washington. New coach Hue Jackson works well with the position.
Colts QB Andrew Luck is expected to make his first regular-season start since Nov. 8, when his injury-ravaged season ended.
At Arizona.
The Redskins added All-Pro Josh Norman at cornerback to bolster a D that ranked 25th against the pass. They also need to figure out their running game.
Also Sunday, it's Green Bay at Jacksonville, the New York Giants at Dallas, Minnesota at Tennessee, Miami at Seattle, San Diego at Kansas City, Oakland at New Orleans, Cincinnati at the New York Jets, Buffalo a